Is Lectin Complement Pathway Dependent Gastrointestinal Ischemia-Reperfusion Injury
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چکیده
منابع مشابه
Gastrointestinal ischemia-reperfusion injury is lectin complement pathway dependent without involving C1q.
Complement activation plays an important role in local and remote tissue injury associated with gastrointestinal ischemia-reperfusion (GI/R). The role of the classical and lectin complement pathways in GI/R injury was evaluated using C1q-deficient (C1q KO), MBL-A/C-deficient (MBL-null), complement factor 2- and factor B-deficient (C2/fB KO), and wild-type (WT) mice. Gastrointestinal ischemia (2...
متن کاملInhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury.
BACKGROUND Complement consists of a complex cascade of proteins involved in innate and adaptive immunity. The cascade can be activated through 3 distinct mechanisms, designated the classical, alternative, and lectin pathways. Although complement is widely accepted as participating in the pathophysiology of ischemia-reperfusion injury, the specific role of the lectin pathway has not been address...
متن کاملMannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury.
The mannose-binding lectin (MBL), a circulating pattern recognition molecule, recognizes a wide range of infectious agents with resultant initiation of the complement cascade in an Ab-independent manner. MBL recognizes infectious non-self and altered self in the guise of apoptotic and necrotic cells. In this study, we demonstrate that mice lacking MBL, and hence are devoid of MBL-dependent lect...
متن کاملMannose-binding lectin binds IgM to activate the lectin complement pathway in vitro and in vivo.
Recent evidence has implicated a role for the MBL-dependent lectin pathway in gastrointestinal and myocardial ischemia/reperfusion (I/R)-induced injury. However, previous studies have implicated IgM and the classical pathway as initiators of complement activation following I/R. Thus, we investigated the potential interaction between MBL and IgM leading to complement activation. Using surface pl...
متن کاملMyocardial ischemia and reperfusion injury is dependent on both IgM and mannose-binding lectin.
Complement activation has been shown to play an important role in the inflammation and tissue injury following myocardial ischemia and reperfusion (MI/R). Several recent studies from our laboratory demonstrated the importance of mannose-binding lectin (MBL) as the initiation pathway for complement activation and the resulting pathological effects following MI/R. However, other studies from the ...
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